Modeling and Docking the Endothelin G-Protein-Coupled Receptor
نویسندگان
چکیده
منابع مشابه
G-protein Coupled Receptor Dimerization
A growing body of evidence suggests that GPCRs exist and function as dimers or higher oligomers. The evidence for GPCR dimerization comes from biochemical, biophysical and functional studies. In addition, researchers have shown the occurrence of heterodimerization between different members of the GPCR family. Two receptors can interact with each other to make a dimer through their extracellular...
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Signal transduction is the process by which a cell converts one kind of signal or stimulus into another. In this process, G-protein coupled receptors (GPCRs) are considered a major class of membrane protein receptors. GPCRs play a critical role in signal transduction, and they are important pharmacological drug targets. Motivated by some specific experimental data, we construct a mathematical m...
متن کاملModeling of G-protein-coupled receptor signaling pathways.
G-protein-coupled receptors (GPCRs)2 are the largest family of cell membrane receptors. An estimated 50% of current pharmaceuticals target GPCRs (1), suggesting that further increases in our understanding ofGPCRs and the signaling pathways they initiate will lead to new drug targets. Mathematical and computationalmodeling (here, simply “modeling”) has a substantial history in modern biology and...
متن کاملG-Protein Coupled Receptor Dimerization
A growing body of evidence suggests that GPCRs exist and function as dimers or higher oligomers. The evidence for GPCR dimerization comes from biochemical, biophysical and functional studies. In addition, researchers have shown the occurrence of heterodimerization between different members of the GPCR family. Two receptors can interact with each other to make a dimer through their extracellular...
متن کاملG protein-coupled receptor rhodopsin.
The rhodopsin crystal structure provides a structural basis for understanding the function of this and other G protein-coupled receptors (GPCRs). The major structural motifs observed for rhodopsin are expected to carry over to other GPCRs, and the mechanism of transformation of the receptor from inactive to active forms is thus likely conserved. Moreover, the high expression level of rhodopsin ...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2000
ISSN: 0006-3495
DOI: 10.1016/s0006-3495(00)76543-x